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Dear Ms. Brennan,
Thank you for posting your request on History Hub!
We searched the National Archives Catalog and located 16 record series that include records created by the U.S. District Court for the Eastern District of Pennsylvania during the 1840s, of which 9 related to bankruptcy cases. These records are in the custody of the National Archives at Philadelphia (RE-PA). To request a search for files relating to specific cases, please contact RE-PA via email at firstname.lastname@example.org
We hope this information is helpful. Best of luck with your research!