This may be his arrival. You did not give us a birth year, name of his spouse &/or children, or where he lived in the US, so I just picked the Christian Wetzel that arrived near 1850 that I could find.
He is the last person on the list and he is traveling with Fritz Wetzel, age 27. They are in the ship Liverpool, sailing from Antwerp & arriving in NYC on 18 Jun 1849.
Dear Lumen Wetzel,
Thank you for posting your request on History Hub!
We searched the Access to Archival Databases (AAD) and located the Data Files Relating to the Immigration of Germans to the United States, documenting the period 1850 - 1897 in the Records of the Center for Immigration Research (Collection CIR) that includes a file pertaining to a Christian Wetzel from Hessen and arrived on 08/19/1853 in Philadelphia via the SS Vesta from the Port of Bremen.
We searched the National Archives Catalog and located the Index to Vessels Entering the Port of Philadelphia, ca. 1800 - ca. 1880 (M360) in the Records of the U.S. Customs Service (Record Group 36) that consists of index cards which note the name of the ship, the ship type, the port of departure, and the month, day, and year of arrival at Philadelphia. M360 serves as an index to National Archives Microfilm Publication No. M425, Passenger Lists of Vessels Arriving at Philadelphia, Pennsylvania, 1800-1882 (108 rolls). For more information about the index and the SS Vesta, please contact the National Archives at Philadelphia (RE-PA) at firstname.lastname@example.org.
M425 has been digitized and made available online by Ancestry and FamilySearch. There may be a fee for using Ancestry. Instead, please check for access at your local library as many library systems subscribe to these sites, making them free for their patrons.
We also located Passenger Lists, 1817 - 1897 of vessels arriving at the Port of New York in the Records of the U.S. Customs Service (Record Group 36) that may contain a list of the SS Liverpool for June 18, 1849 which includes a Christian Wetzel. For more information about these records, please contact the National Archives at New York (RE-NY) at email@example.com.
We also located Baltimore, Maryland Customs Records and Vessel Passenger Lists, 1820 - 1898 in the Records of the U.S. Customs Service (Record Group 36) that may contain a list of the SS Bessel for November 29, 1852 which includes a Christian Wetzel. For more information about these records, please email the National Archives at Washington, DC - Textual Reference (RDT1) at firstname.lastname@example.org.
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Prior to September 27, 1906, any "court of record" (municipal, county, state, or Federal) could grant United States citizenship. Often petitioners went to the court most geographically convenient for them. As a general rule, the National Archives does not have naturalization records created in state or local courts. However, a few indexes and records have been donated to the National Archives from counties, states, and local courts. Researchers should contact the National Archives facility serving the state in which the petitioner resided to determine if records from lower courts are available. In certain cases county court naturalization records maintained by the National Archives are available as microfilm publications. Records from state and local courts are often at state archives or county historical societies.
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We hope this is helpful. Best of luck with your family research!