Dear Ms. Shorter,
Thank you for posting your request on History Hub!
By the time your great grandmother was born, the Cherokee had long been pushed out their original homes in South Carolina. While some Cherokee decided to stay behind, the records were not properly maintained by the government. You may wish to search for your lineage through removal rolls of the early 1800s, and Oklahoma Territory records as they may show up in reference to the Dawes Act.
We suggest that you review the National Archives website American Indian Records in the National Archives and Researching an Individual or Family for background information and tips on how to determine the tribe that your relative may have been a member of and to ascertain the records that might be useful to your research. There is an all encompassing resource for Native American individuals which are found among the Records of the Bureau of Indian Affairs (Record Group 75). These records are organized by tribal nation. Once you determine the state where your relatives may have lived via other sources, then you should be able to look at nearby tribes and bands. Please note that many American Indians who left reservations will not be captured in Federal records which would make identifying tribal affiliations even more difficult.
We hope this is helpful! Best of luck with your family research!
[Information provided by Cody White, Subject Matter Expert]